{"entity":{"id":"minpp1","kind":"target","name":"MINPP1","aka":["multiple inositol-polyphosphate phosphatase 1","Multiple inositol polyphosphate phosphatase 1"],"tldr":"MINPP1 (Multiple inositol polyphosphate phosphatase 1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.","summary":"Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.75, genetic association 0.71, somatic mutation 0.55, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7102","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7102"},{"label":"UniProt Q9UNW1","url":"https://www.uniprot.org/uniprotkb/Q9UNW1/entry"},{"label":"NCBI Gene 9562","url":"https://www.ncbi.nlm.nih.gov/gene/9562"},{"label":"Ensembl ENSG00000107789","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107789"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MINPP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7102","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7102","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UNW1","url":"https://www.uniprot.org/uniprotkb/Q9UNW1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000107789","url":"https://platform.opentargets.org/target/ENSG00000107789/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: thyroid cancer 0.62 (GraphQL API, CC0)"}],"hgnc":"HGNC:7102","ensembl":"ENSG00000107789","uniprot":"Q9UNW1","entrez":"9562","biology":"Multiple inositol polyphosphate phosphatase that hydrolyses 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolysing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of haemoglobin. Location: Endoplasmic reticulum lumen; Secreted; Cell membrane (UniProt). Locus 10q23.2 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.62 with thyroid cancer (MONDO_0002108)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/minpp1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}