{"entity":{"id":"mir-sentinel","kind":"drug","name":"miR Sentinel","aka":["Sentinel PCa Test","miR Sentinel prostate test"],"tldr":"A urine test that reads small RNAs from tiny vesicles to detect prostate cancer and judge its grade, so far validated in a case-control study.","summary":"MiRNA Scientific calls it \"the first and only non-invasive liquid biopsy urine test that accurately detects, classifies and can monitor prostate cancer at the molecular level\" (the maker's claim). Its first report interrogated small non-coding RNAs from urinary vesicles of 235 participants on microarrays and was then validated in a case-control sample of 1,436 subjects with 94 per cent sensitivity and 92 per cent specificity (Wang 2020). No regulatory or coverage status was found.","status":"emerging","asOf":"2026-11-04","links":[{"label":"MiRNA Scientific","url":"https://mirnascientific.com"}],"tags":["test","rna"],"related":["exodx-prostate"],"cancers":["prostate"],"sections":[],"technologies":["liquid-rna-biopsy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-wang-urinary-exosome-small-rna-prostate-j-urol-2020"],"journals":[],"dependsOn":[],"notes":[],"brand":"miR Sentinel","modality":"Urine extracellular vesicle small non-coding RNA test (prostate cancer)","mechanism":"Small non-coding RNAs from urinary vesicles are read on microarrays and classified to separate prostate cancer from no cancer and low from higher grade.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/mir-sentinel/","neighbours":{"drug":[{"id":"exodx-prostate","kind":"drug","name":"ExoDx Prostate (IntelliScore)","route":"/drugs/exodx-prostate/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"liquid-rna-biopsy","kind":"technology","name":"Liquid RNA biopsy (cell-free, vesicle and platelet RNA)","route":"/technologies/liquid-rna-biopsy/"}],"paper":[{"id":"paper-wang-urinary-exosome-small-rna-prostate-j-urol-2020","kind":"paper","name":"Expression of Small Noncoding RNAs in Urinary Exosomes Classifies Prostate Cancer into Indolent and Aggressive Disease","route":"/key-papers/paper-wang-urinary-exosome-small-rna-prostate-j-urol-2020/"}]}}