{"entity":{"id":"mir21","kind":"target","name":"MIR21","aka":["microRNA 21","hsa-mir-21","MIR-21","MIRN21"],"tldr":"MIR21 (microRNA 21) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"UniProt has no function text for this gene; HGNC names it \"microRNA 21\".\n\nCIViC holds 4 clinical evidence items and 0 assertions across 1 variant, naming Cisplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:31586","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31586"},{"label":"NCBI Gene 406991","url":"https://www.ncbi.nlm.nih.gov/gene/406991"},{"label":"Ensembl ENSG00000284190","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000284190"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["micrornas-in-cancer"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Malignant Astrocytoma; Glioma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MIR21","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:31586","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31586","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"CIViC gene MIR21","url":"https://civicdb.org/features/24929","note":"4 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma, Malignant Astrocytoma, Glioma (GraphQL API, CC0)"}],"hgnc":"HGNC:31586","ensembl":"ENSG00000284190","entrez":"406991","biology":"UniProt has no function text for this gene; HGNC names it \"microRNA 21\". Locus 17q23.1 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/mir21/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"pathway":[{"id":"micrornas-in-cancer","kind":"pathway","name":"MicroRNAs in cancer","route":"/pathways/micrornas-in-cancer/"}]}}