{"entity":{"id":"mir218-1","kind":"target","name":"MIR218-1","aka":["microRNA 218-1","hsa-mir-218-1","MIRN218-1"],"tldr":"MIR218-1 (microRNA 218-1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Pancreatic ductal adenocarcinoma.","summary":"UniProt has no function text for this gene; HGNC names it \"microRNA 218-1\".\n\nCIViC holds 3 clinical evidence items and 0 assertions across 2 variants.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:31595","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31595"},{"label":"NCBI Gene 407000","url":"https://www.ncbi.nlm.nih.gov/gene/407000"},{"label":"Ensembl ENSG00000207732","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000207732"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["colorectal","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MIR218-1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:31595","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31595","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"CIViC gene MIR218-1","url":"https://civicdb.org/features/24938","note":"3 evidence items, 0 assertions, 2 variants; diseases: Colorectal Cancer, Pancreatic Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:31595","ensembl":"ENSG00000207732","entrez":"407000","biology":"UniProt has no function text for this gene; HGNC names it \"microRNA 218-1\". Locus 4p15.31 (HGNC).","whereFound":["Colorectal cancer: CIViC evidence names this disease","Pancreatic ductal adenocarcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/mir218-1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}