{"entity":{"id":"mlf1","kind":"target","name":"MLF1","aka":["myeloid leukemia factor 1","Myeloid leukemia factor 1"],"tldr":"MLF1 (Myeloid leukaemia factor 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Lung cancer.","summary":"Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.49, genetic association 0.00, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7125","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7125"},{"label":"UniProt P58340","url":"https://www.uniprot.org/uniprotkb/P58340/entry"},{"label":"NCBI Gene 4291","url":"https://www.ncbi.nlm.nih.gov/gene/4291"},{"label":"Ensembl ENSG00000178053","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178053"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MLF1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7125","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7125","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P58340","url":"https://www.uniprot.org/uniprotkb/P58340/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000178053","url":"https://platform.opentargets.org/target/ENSG00000178053/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: lung cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:7125","ensembl":"ENSG00000178053","uniprot":"P58340","entrez":"4291","biology":"Involved in lineage commitment of primary haemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. Location: Cytoplasm; Nucleus; Cell projection, cilium; Cytoplasm, cytoskeleton, cilium basal body (UniProt). Locus 3q25.32 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)"],"targetClass":"other","prevalence":[]},"route":"/targets/mlf1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"}]}}