{"entity":{"id":"mlh3","kind":"target","name":"MLH3","aka":["mutL homolog 3","DNA mismatch repair protein Mlh3"],"tldr":"MLH3 (DNA mismatch repair protein Mlh3) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Endometrial cancer.","summary":"Probably involved in the repair of mismatches in DNA.\n\nOpen Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.73, genetic association 0.91, somatic mutation 0.55, genetic literature 0.49).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7128","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7128"},{"label":"UniProt Q9UHC1","url":"https://www.uniprot.org/uniprotkb/Q9UHC1/entry"},{"label":"NCBI Gene 27030","url":"https://www.ncbi.nlm.nih.gov/gene/27030"},{"label":"Ensembl ENSG00000119684","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119684"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal","endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MLH3","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7128","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7128","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UHC1","url":"https://www.uniprot.org/uniprotkb/Q9UHC1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000119684","url":"https://platform.opentargets.org/target/ENSG00000119684/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.68, endometrial cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:7128","ensembl":"ENSG00000119684","uniprot":"Q9UHC1","entrez":"27030","biology":"Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt). Locus 14q24.3 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.68 with colorectal cancer (MONDO_0005575)","Endometrial cancer: Open Targets association 0.53 with endometrial cancer (MONDO_0011962)"],"targetClass":"other","prevalence":[]},"route":"/targets/mlh3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}