{"entity":{"id":"mllt10","kind":"target","name":"MLLT10","aka":["MLLT10 histone lysine methyltransferase DOT1L cofactor","AF10"],"tldr":"MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Ovarian cancer, Leukaemia and 2 more.","summary":"Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.\n\nOpen Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.87, animal model 0.47, genetic association 0.69, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16063","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16063"},{"label":"UniProt P55197","url":"https://www.uniprot.org/uniprotkb/P55197/entry"},{"label":"NCBI Gene 8028","url":"https://www.ncbi.nlm.nih.gov/gene/8028"},{"label":"Ensembl ENSG00000078403","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078403"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","ovarian","leukaemia","non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MLLT10","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16063","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16063","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P55197","url":"https://www.uniprot.org/uniprotkb/P55197/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000078403","url":"https://platform.opentargets.org/target/ENSG00000078403/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: ovarian cancer 0.57, acute lymphoblastic leukaemia 0.51, non-Hodgkin lymphoma 0.53, breast cancer 0.64, leukaemia 0.57 (GraphQL API, CC0)"}],"hgnc":"HGNC:16063","ensembl":"ENSG00000078403","uniprot":"P55197","entrez":"8028","biology":"Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. Location: Nucleus (UniProt). Locus 10p12.31 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)","Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.53 with non-Hodgkin lymphoma (MONDO_0018908)","Acute lymphoblastic leukaemia: Open Targets association 0.51 with acute lymphoblastic leukaemia (MONDO_0004967)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/mllt10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}