{"entity":{"id":"mn1","kind":"target","name":"MN1","aka":["MN1 proto-oncogene, transcriptional regulator","Transcriptional activator MN1","MGCR1-PEN","MGCR1"],"tldr":"MN1 (Transcriptional activator MN1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Colorectal cancer, Skin cancer and 1 more.","summary":"Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL.\n\nCIViC holds 3 clinical evidence items and 2 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.95, animal model 0.45, genetic association 0.52, somatic mutation 0.82).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7180","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7180"},{"label":"UniProt Q10571","url":"https://www.uniprot.org/uniprotkb/Q10571/entry"},{"label":"NCBI Gene 4330","url":"https://www.ncbi.nlm.nih.gov/gene/4330"},{"label":"Ensembl ENSG00000169184","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169184"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["breast-cancer","colorectal","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Astroblastoma, MN1-altered."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MN1","role":["biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7180","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7180","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q10571","url":"https://www.uniprot.org/uniprotkb/Q10571/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MN1","url":"https://civicdb.org/features/3564","note":"3 evidence items, 2 assertions, 1 variants; diseases: Astroblastoma, MN1-altered (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000169184","url":"https://platform.opentargets.org/target/ENSG00000169184/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: colorectal cancer 0.52, melanoma 0.51, skin cancer 0.51, breast cancer 0.60 (GraphQL API, CC0)"}],"hgnc":"HGNC:7180","ensembl":"ENSG00000169184","uniprot":"Q10571","entrez":"4330","biology":"Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumour suppression. Location: Nucleus (UniProt). Locus 22q12.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/mn1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}