{"entity":{"id":"moma-989","kind":"drug","name":"MOMA-989","aka":[],"tldr":"MOMA-989 is an experimental small molecule from MOMA Therapeutics, in preclinical development for homologous recombination deficient tumours.","summary":"MOMA-989 is a small molecule (oral) from MOMA Therapeutics. An oral, highly potent, brain-penetrant selective PARP1 inhibitor, planned for homologous recombination deficient tumours alone and with MOMA-313. Its furthest stage is preclinical development, for homologous recombination deficient tumours. No clinical trial naming it is registered on ClinicalTrials.gov. In-licensed January 2025 from an unnamed US biopharmaceutical partner; MOMA then anticipated an IND by end of 2025. No ClinicalTrials.gov study names MOMA-989 (query.intr search, 3 Nov 2026), so it is kept at preclinical. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"MOMA Therapeutics: momatx.com","url":"https://momatx.com/posts/moma-therapeutics-provides-corporate-update-and-announces-exclusive-license-agreement-for-selective-parp1-inhibitor/"},{"label":"MOMA Therapeutics: momatx.com","url":"https://momatx.com/posts/moma-therapeutics-provides-corporate-update-and-announces-exclusive-license-agreement-for-selective-parp1-inhibitor/"}],"tags":["pipeline"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["parp"],"drugs":[],"companies":["moma-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"MOMA-989","modality":"Small molecule (oral)","mechanism":"An oral, highly potent, brain-penetrant selective PARP1 inhibitor, planned for homologous recombination deficient tumours alone and with MOMA-313.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/moma-989/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"company":[{"id":"moma-therapeutics","kind":"company","name":"MOMA Therapeutics","route":"/companies/moma-therapeutics/"}]}}