{"entity":{"id":"mov10","kind":"target","name":"MOV10","aka":["Mov10 RNA helicase","RNA helicase MOV-10","gb110","MGC2948","fSAP113"],"tldr":"MOV10 (RNA helicase MOV-10) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"5'-3' RNA helicase. Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.76, animal model 0.29, genetic association 0.32).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7200","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7200"},{"label":"UniProt Q9HCE1","url":"https://www.uniprot.org/uniprotkb/Q9HCE1/entry"},{"label":"NCBI Gene 4343","url":"https://www.ncbi.nlm.nih.gov/gene/4343"},{"label":"Ensembl ENSG00000155363","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155363"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MOV10","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7200","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7200","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HCE1","url":"https://www.uniprot.org/uniprotkb/Q9HCE1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000155363","url":"https://platform.opentargets.org/target/ENSG00000155363/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:7200","ensembl":"ENSG00000155363","uniprot":"Q9HCE1","entrez":"4343","biology":"5'-3' RNA helicase. Involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. Location: Cytoplasm, P-body; Cytoplasm, Cytoplasmic ribonucleoprotein granule; Cytoplasm, Stress granule; Nucleus (UniProt). Locus 1p13.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/mov10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}