{"entity":{"id":"mprip","kind":"target","name":"MPRIP","aka":["myosin phosphatase Rho interacting protein","Myosin phosphatase Rho-interacting protein","RHOIP3","M-RIP","p116Rip"],"tldr":"MPRIP (Myosin phosphatase Rho-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Renal cell carcinoma.","summary":"Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibres in smooth muscle cells through stabilisation of actin fibres by phosphorylated myosin.\n\nOpen Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.24, affected pathway 0.89, genetic association 0.78, somatic mutation 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:30321","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30321"},{"label":"UniProt Q6WCQ1","url":"https://www.uniprot.org/uniprotkb/Q6WCQ1/entry"},{"label":"NCBI Gene 23164","url":"https://www.ncbi.nlm.nih.gov/gene/23164"},{"label":"Ensembl ENSG00000133030","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000133030"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal","rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MPRIP","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:30321","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30321","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6WCQ1","url":"https://www.uniprot.org/uniprotkb/Q6WCQ1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000133030","url":"https://platform.opentargets.org/target/ENSG00000133030/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.64, renal cell carcinoma 0.62 (GraphQL API, CC0)"}],"hgnc":"HGNC:30321","ensembl":"ENSG00000133030","uniprot":"Q6WCQ1","entrez":"23164","biology":"Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibres in smooth muscle cells through stabilisation of actin fibres by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibres in neuronal cells. Location: Cytoplasm, cytoskeleton (UniProt). Locus 17p11.2 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.64 with colorectal cancer (MONDO_0005575)","Renal cell carcinoma: Open Targets association 0.62 with renal cell carcinoma (MONDO_0005086)"],"targetClass":"other","prevalence":[]},"route":"/targets/mprip/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}