{"entity":{"id":"mrna-protein-concordance","kind":"term","name":"mRNA to protein concordance","aka":["mRNA-protein concordance","mRNA protein concordance","transcript-protein correlation","mRNA-protein correlation","proteogenomic concordance"],"tldr":"mRNA to protein concordance is how well the amount of a gene's messenger RNA tracks the amount of the protein it codes for; for many genes it tracks poorly.","summary":"Proteogenomics combines proteomics, genomics and transcriptomics (Wikipedia); CPTAC applied it to TCGA-linked tumours and measured, gene by gene, how well transcript levels predict protein levels. Correlations are strong for some genes and near zero or negative for others because of post-transcriptional and post-translational regulation and protein complex stoichiometry, so an expression model is not a protein model, and phosphorylation-driven pathway activity is invisible to RNA.","asOf":"2026-09-24","wikipedia":"https://en.wikipedia.org/wiki/Proteogenomics","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Proteogenomics"}],"tags":["cansim-terms"],"related":["cptac","cancer-ai-vocabulary"],"cancers":[],"sections":[],"technologies":["proteomics"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["post-transcriptional-regulation-term","pathway-activation-state"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Listed in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme; CanSim page path /terms/mrna-protein-concordance."],"provenance":{"editedBy":"OnCo CanSim terms wave (Wikipedia summaries, standards and project pages, GDC and FDA pages, Europe PMC)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"category":"Cancer biology"},"route":"/terms/mrna-protein-concordance/","neighbours":{"collection":[{"id":"cptac","kind":"collection","name":"CPTAC (Clinical Proteomic Tumor Analysis Consortium)","route":"/collections/cptac/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"mass-spec-proteome","kind":"term","name":"Deep mass-spectrometry proteome (CPTAC)","route":"/terms/mass-spec-proteome/"},{"id":"pathway-activation-state","kind":"term","name":"Pathway activation state (phosphosignalling)","route":"/terms/pathway-activation-state/"},{"id":"post-transcriptional-regulation-term","kind":"term","name":"Post-transcriptional and post-translational regulation","route":"/terms/post-transcriptional-regulation-term/"},{"id":"spearman-correlation","kind":"term","name":"Spearman rank correlation","route":"/terms/spearman-correlation/"}],"technology":[{"id":"proteomics","kind":"technology","name":"Proteomics & phosphoproteomics","route":"/technologies/proteomics/"}],"target":[{"id":"dclk1","kind":"target","name":"DCLK1","route":"/targets/dclk1/"},{"id":"dnajc12","kind":"target","name":"DNAJC12","route":"/targets/dnajc12/"},{"id":"e2f7","kind":"target","name":"E2F7","route":"/targets/e2f7/"},{"id":"phlpp2","kind":"target","name":"PHLPP2","route":"/targets/phlpp2/"}]}}