{"entity":{"id":"mrtfa","kind":"target","name":"MRTFA","aka":["myocardin related transcription factor A","Myocardin-related transcription factor A","KIAA1438","MRTF-A","MKL1"],"tldr":"MRTFA (Myocardin-related transcription factor A) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Skin cancer, Lung cancer and 1 more.","summary":"Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.52, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14334","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14334"},{"label":"UniProt Q969V6","url":"https://www.uniprot.org/uniprotkb/Q969V6/entry"},{"label":"NCBI Gene 57591","url":"https://www.ncbi.nlm.nih.gov/gene/57591"},{"label":"Ensembl ENSG00000196588","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196588"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","skin-cancer","lung-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MRTFA","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14334","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14334","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q969V6","url":"https://www.uniprot.org/uniprotkb/Q969V6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196588","url":"https://platform.opentargets.org/target/ENSG00000196588/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: melanoma 0.51, skin cancer 0.54, breast cancer 0.62, lung cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:14334","ensembl":"ENSG00000196588","uniprot":"Q969V6","entrez":"57591","biology":"Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. Location: Cytoplasm; Nucleus (UniProt). Locus 22q13.1-q13.2 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.62 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)","Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/mrtfa/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}