{"entity":{"id":"msi2","kind":"target","name":"MSI2","aka":["musashi RNA binding protein 2","RNA-binding protein Musashi homolog 2"],"tldr":"MSI2 (RNA-binding protein Musashi homolog 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Skin cancer and Neuroblastoma.","summary":"RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.\n\nOpen Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.52, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Neuroblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18585","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18585"},{"label":"UniProt Q96DH6","url":"https://www.uniprot.org/uniprotkb/Q96DH6/entry"},{"label":"NCBI Gene 124540","url":"https://www.ncbi.nlm.nih.gov/gene/124540"},{"label":"Ensembl ENSG00000153944","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153944"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","skin-cancer","neuroblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MSI2","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18585","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18585","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96DH6","url":"https://www.uniprot.org/uniprotkb/Q96DH6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000153944","url":"https://platform.opentargets.org/target/ENSG00000153944/associations","note":"association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: skin cancer 0.50, breast cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen MSI2","url":"https://www.intogen.org/search?gene=MSI2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:18585","ensembl":"ENSG00000153944","uniprot":"Q96DH6","entrez":"124540","biology":"RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Location: Cytoplasm (UniProt). Locus 17q22 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)","Neuroblastoma: IntOGen driver in 1 cohort (NBL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/msi2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}