{"entity":{"id":"mskcc-motzer-rcc","kind":"term","name":"MSKCC (Motzer) risk groups for advanced kidney cancer","aka":["MSKCC risk","MSKCC criteria","Motzer criteria","Motzer score","MSKCC favourable risk","MSKCC poor risk"],"tldr":"The MSKCC (Motzer) model sorts advanced kidney cancer into favourable, intermediate and poor risk by counting five factors; the IMDC model later replaced it, but trials and labels still use it.","summary":"From 670 patients with advanced renal cell carcinoma in 24 Memorial Sloan-Kettering trials between 1975 and 1996, Motzer and colleagues (Journal of Clinical Oncology 1999) identified five factors linked to shorter survival: Karnofsky performance status below 80%, LDH above 1.5 times the upper limit of normal, haemoglobin below the lower limit of normal, corrected calcium above 10 mg/dl, and no prior nephrectomy. Patients with none were favourable risk (25% of patients, median survival 20 months in that era), one or two intermediate (53%, 10 months), and three or more poor (22%, 4 months). Survival with current immunotherapy combinations is far longer than in this pre-targeted-therapy cohort.","asOf":"2026-11-04","links":[{"label":"Motzer et al., Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma (J Clin Oncol 1999)","url":"https://doi.org/10.1200/jco.1999.17.8.2530"}],"tags":[],"related":["imdc-risk","leibovich-score","staging-systems"],"cancers":["rcc","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical"},"route":"/terms/mskcc-motzer-rcc/","neighbours":{"term":[{"id":"staging-systems","kind":"term","name":"Disease-specific staging and risk systems (FIGO, Ann Arbor, IPI, R-ISS, ELN, IMDC)","route":"/terms/staging-systems/"},{"id":"imdc-risk","kind":"term","name":"IMDC risk groups (favourable / intermediate / poor)","route":"/terms/imdc-risk/"},{"id":"leibovich-score","kind":"term","name":"Leibovich score (kidney cancer recurrence risk after surgery)","route":"/terms/leibovich-score/"}],"cancer":[{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}