{"entity":{"id":"msmb","kind":"target","name":"MSMB","aka":["microseminoprotein beta","Beta-microseminoprotein","PSP-94","PSP57","PSP94","PN44"],"tldr":"MSMB (Beta-microseminoprotein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"UniProt has no function text for P08118; HGNC names it \"microseminoprotein beta\".\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.93, animal model 0.30, genetic association 0.69, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7372","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7372"},{"label":"UniProt P08118","url":"https://www.uniprot.org/uniprotkb/P08118/entry"},{"label":"NCBI Gene 4477","url":"https://www.ncbi.nlm.nih.gov/gene/4477"},{"label":"Ensembl ENSG00000263639","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000263639"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MSMB","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7372","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7372","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P08118","url":"https://www.uniprot.org/uniprotkb/P08118/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000263639","url":"https://platform.opentargets.org/target/ENSG00000263639/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: prostate cancer 0.63 (GraphQL API, CC0)"}],"hgnc":"HGNC:7372","ensembl":"ENSG00000263639","uniprot":"P08118","entrez":"4477","biology":"UniProt has no function text for P08118; HGNC names it \"microseminoprotein beta\". Location: Secreted (UniProt). Locus 10q11.22 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.63 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/msmb/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}