{"entity":{"id":"msn","kind":"target","name":"MSN","aka":["moesin","Moesin"],"tldr":"MSN (Moesin) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Renal cell carcinoma, Basal cell carcinoma and 3 more.","summary":"Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes affected pathway 0.76, literature 0.98, genetic association 0.04, somatic mutation 0.47, animal model 0.62). IntOGen calls it a driver in 4 cohorts (1 activating, 2 loss-of-function), covering Basal Cell Carcinoma, Renal Clear Cell Carcinoma, Oesophageal Adenocarcinoma, Oesophageal Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7373","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7373"},{"label":"UniProt P26038","url":"https://www.uniprot.org/uniprotkb/P26038/entry"},{"label":"NCBI Gene 4478","url":"https://www.ncbi.nlm.nih.gov/gene/4478"},{"label":"Ensembl ENSG00000147065","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147065"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["esophageal","rcc","basal-cell-carcinoma","clear-cell-rcc","oesophageal-adenocarcinoma","oesophageal-squamous-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MSN","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:7373","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7373","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P26038","url":"https://www.uniprot.org/uniprotkb/P26038/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000147065","url":"https://platform.opentargets.org/target/ENSG00000147065/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"},{"label":"IntOGen MSN","url":"https://www.intogen.org/search?gene=MSN","note":"driver in 4 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7373","ensembl":"ENSG00000147065","uniprot":"P26038","entrez":"4478","biology":"Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages. Location: Cell membrane; Cytoplasm, cytoskeleton; Apical cell membrane; Cell projection, microvillus membrane (UniProt). Locus Xq12 (HGNC).","whereFound":["Oesophageal cancer: IntOGen driver in 2 cohorts (ESCA, ESCC)","Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)","Clear cell renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)","Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)","Oesophageal squamous cell carcinoma: IntOGen driver in 1 cohort (ESCC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/msn/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"oesophageal-squamous-cell-carcinoma","kind":"cancer","name":"Oesophageal squamous cell carcinoma","route":"/cancers/oesophageal-squamous-cell-carcinoma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}