{"entity":{"id":"msr1","kind":"target","name":"MSR1","aka":["macrophage scavenger receptor 1","Macrophage scavenger receptor types I and II","SCARA1","CD204","SR-AI","SR-AII","SR-AIII","SR-A"],"tldr":"MSR1 (Macrophage scavenger receptor types I and II) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.73, genetic literature 0.30).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7376","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7376"},{"label":"UniProt P21757","url":"https://www.uniprot.org/uniprotkb/P21757/entry"},{"label":"NCBI Gene 4481","url":"https://www.ncbi.nlm.nih.gov/gene/4481"},{"label":"Ensembl ENSG00000038945","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000038945"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MSR1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7376","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7376","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P21757","url":"https://www.uniprot.org/uniprotkb/P21757/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000038945","url":"https://platform.opentargets.org/target/ENSG00000038945/associations","note":"association with cancer (MONDO_0004992) 0.58;  (GraphQL API, CC0)"}],"hgnc":"HGNC:7376","ensembl":"ENSG00000038945","uniprot":"P21757","entrez":"4481","biology":"Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognises and internalises modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidised LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense. Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signalling. Does not internalise acetylated LDL. Location: Cell membrane (UniProt). Locus 8p22 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/msr1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}