{"entity":{"id":"mt-304","kind":"drug","name":"MT-304","aka":[],"tldr":"MT-304 is an experimental in vivo CAR therapy from CREATE Medicines, in phase 1 trials for solid tumours that carry HER2.","summary":"MT-304 is an in vivo CAR therapy: mRNA in lipid nanoparticles that programmes NK and myeloid cells from CREATE Medicines. Messenger RNA in lipid nanoparticles makes the patient's own NK cells and myeloid cells carry a chimeric antigen receptor against HER2. The phase 1 study NCT07334119 tests it alone and with nivolumab in HER2-expressing solid tumours. Whether it works in people has not been established.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"CREATE Medicines","url":"https://createmedicines.com/"},{"label":"ClinicalTrials.gov NCT07334119","url":"https://clinicaltrials.gov/study/NCT07334119"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["her2"],"drugs":[],"companies":["create-medicines"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07334119"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors, investor portfolios (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-04"},"code":"MT-304","modality":"In vivo CAR therapy: mRNA in lipid nanoparticles that programmes NK and myeloid cells","mechanism":"Messenger RNA in lipid nanoparticles makes the patient's own NK cells and myeloid cells carry a chimeric antigen receptor against HER2.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/mt-304/","neighbours":{"target":[{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"}],"company":[{"id":"create-medicines","kind":"company","name":"CREATE Medicines","route":"/companies/create-medicines/"}],"trial":[{"id":"nct07334119","kind":"trial","name":"Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MT-304 in Adults With Advanced HER2-Expressing Solid Tumors","route":"/trials/nct07334119/"}]}}