{"entity":{"id":"mt-cyb","kind":"target","name":"MT-CYB","aka":["mitochondrially encoded cytochrome b","Cytochrome b","UQCR3","MTCYB"],"tldr":"MT-CYB (Cytochrome b) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.29, genetic association 0.84).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7427","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7427"},{"label":"UniProt P00156","url":"https://www.uniprot.org/uniprotkb/P00156/entry"},{"label":"NCBI Gene 4519","url":"https://www.ncbi.nlm.nih.gov/gene/4519"},{"label":"Ensembl ENSG00000198727","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198727"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MT-CYB","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7427","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7427","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P00156","url":"https://www.uniprot.org/uniprotkb/P00156/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198727","url":"https://platform.opentargets.org/target/ENSG00000198727/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:7427","ensembl":"ENSG00000198727","uniprot":"P00156","entrez":"4519","biology":"Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/mt-cyb/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}