{"entity":{"id":"mt-nd6","kind":"target","name":"MT-ND6","aka":["mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6","NADH-ubiquinone oxidoreductase chain 6","NAD6","ND6","MTND6"],"tldr":"MT-ND6 (NADH-ubiquinone oxidoreductase chain 6) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes clinical 0.67, literature 0.29, genetic association 0.63, somatic mutation 0.18, animal model 0.33).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7462","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7462"},{"label":"UniProt P03923","url":"https://www.uniprot.org/uniprotkb/P03923/entry"},{"label":"NCBI Gene 4541","url":"https://www.ncbi.nlm.nih.gov/gene/4541"},{"label":"Ensembl ENSG00000198695","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198695"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.67. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MT-ND6","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7462","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7462","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P03923","url":"https://www.uniprot.org/uniprotkb/P03923/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198695","url":"https://platform.opentargets.org/target/ENSG00000198695/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:7462","ensembl":"ENSG00000198695","uniprot":"P03923","entrez":"4541","biology":"Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyses electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/mt-nd6/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}