{"entity":{"id":"mutyh","kind":"target","name":"MUTYH","aka":["mutY DNA glycosylase","Adenine DNA glycosylase"],"tldr":"MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.","summary":"Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.\n\nOpen Targets scores its association with cancer at 0.86 (direct and indirect evidence; datatypes genetic literature 0.66, affected pathway 0.87, literature 0.85, genetic association 0.81, somatic mutation 0.91).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7527","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7527"},{"label":"UniProt Q9UIF7","url":"https://www.uniprot.org/uniprotkb/Q9UIF7/entry"},{"label":"NCBI Gene 4595","url":"https://www.ncbi.nlm.nih.gov/gene/4595"},{"label":"Ensembl ENSG00000132781","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000132781"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["colorectal","gastric","breast-cancer","ovarian","skin-cancer","lung-cancer","brain-tumours","endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MUTYH","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7527","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7527","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UIF7","url":"https://www.uniprot.org/uniprotkb/Q9UIF7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000132781","url":"https://platform.opentargets.org/target/ENSG00000132781/associations","note":"association with cancer (MONDO_0004992) 0.86; per-cancer scores at or above 0.5: colorectal cancer 0.78, gastric cancer 0.72, ovarian cancer 0.57, endometrial cancer 0.51, melanoma 0.51, skin cancer 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:7527","ensembl":"ENSG00000132781","uniprot":"Q9UIF7","entrez":"4595","biology":"Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. Location: Nucleus; Mitochondrion (UniProt). Locus 1p34.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.78 with colorectal cancer (MONDO_0005575)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.72 with gastric cancer (MONDO_0001056)","Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254)","Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/mutyh/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"brain-tumours","kind":"cancer","name":"Brain and spinal cord tumours (all types)","route":"/cancers/brain-tumours/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}