{"entity":{"id":"mx2","kind":"target","name":"MX2","aka":["MX dynamin like GTPase 2","Interferon-induced GTP-binding protein Mx2"],"tldr":"MX2 (Interferon-induced GTP-binding protein Mx2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Melanoma.","summary":"Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd).\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.49, animal model 0.41, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7533","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7533"},{"label":"UniProt P20592","url":"https://www.uniprot.org/uniprotkb/P20592/entry"},{"label":"NCBI Gene 4600","url":"https://www.ncbi.nlm.nih.gov/gene/4600"},{"label":"Ensembl ENSG00000183486","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183486"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MX2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7533","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7533","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P20592","url":"https://www.uniprot.org/uniprotkb/P20592/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000183486","url":"https://platform.opentargets.org/target/ENSG00000183486/associations","note":"association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: melanoma 0.54, skin cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:7533","ensembl":"ENSG00000183486","uniprot":"P20592","entrez":"4600","biology":"Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. Location: Cytoplasm; Nucleus; Nucleus, nuclear pore complex (UniProt). Locus 21q22.3 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.54 with melanoma (MONDO_0005105)"],"targetClass":"other","prevalence":[]},"route":"/targets/mx2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}