{"entity":{"id":"mxi1","kind":"target","name":"MXI1","aka":["MAX interactor 1, dimerization protein","Max-interacting protein 1","MXD2","MAD2","bHLHc11"],"tldr":"MXI1 (Max-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognises the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonises MYC transcriptional activity by competing for MAX.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.76, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7534","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7534"},{"label":"UniProt P50539","url":"https://www.uniprot.org/uniprotkb/P50539/entry"},{"label":"NCBI Gene 4601","url":"https://www.ncbi.nlm.nih.gov/gene/4601"},{"label":"Ensembl ENSG00000119950","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119950"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["mitotic-spindle-checkpoint"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MXI1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7534","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7534","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P50539","url":"https://www.uniprot.org/uniprotkb/P50539/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000119950","url":"https://platform.opentargets.org/target/ENSG00000119950/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: prostate cancer 0.59 (GraphQL API, CC0)"}],"hgnc":"HGNC:7534","ensembl":"ENSG00000119950","uniprot":"P50539","entrez":"4601","biology":"Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognises the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonises MYC transcriptional activity by competing for MAX. Location: Nucleus (UniProt). Locus 10q25.2 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/mxi1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"pathway":[{"id":"mitotic-spindle-checkpoint","kind":"pathway","name":"Mitosis & the spindle assembly checkpoint","route":"/pathways/mitotic-spindle-checkpoint/"}]}}