{"entity":{"id":"myb","kind":"target","name":"MYB","aka":["MYB proto-oncogene, transcription factor","Transcriptional activator Myb","c-myb"],"tldr":"MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.","summary":"Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells.\n\nCIViC holds 7 clinical evidence items and 2 assertions across 3 variants. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.44, literature 0.99, genetic association 0.10, somatic mutation 0.98, animal model 0.71).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7545","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7545"},{"label":"UniProt P10242","url":"https://www.uniprot.org/uniprotkb/P10242/entry"},{"label":"NCBI Gene 4602","url":"https://www.ncbi.nlm.nih.gov/gene/4602"},{"label":"Ensembl ENSG00000118513","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118513"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["skin-cancer","breast-cancer","colorectal","leukaemia","non-hodgkin-lymphoma","paediatric-low-grade-glioma","melanoma","oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 7 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Diffuse Astrocytoma, MYB- Or MYBL1-altered; Angiocentric Glioma; Isomorphic Diffuse Glioma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MYB","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7545","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7545","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10242","url":"https://www.uniprot.org/uniprotkb/P10242/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MYB","url":"https://civicdb.org/features/3730","note":"7 evidence items, 2 assertions, 3 variants; diseases: Diffuse Astrocytoma, MYB- Or MYBL1-altered, Angiocentric Glioma, Childhood Low-grade Glioma, Isomorphic Diffuse Glioma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000118513","url":"https://platform.opentargets.org/target/ENSG00000118513/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, melanoma 0.57, non-Hodgkin lymphoma 0.52, skin cancer 0.58, breast cancer 0.56, leukaemia 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:7545","ensembl":"ENSG00000118513","uniprot":"P10242","entrez":"4602","biology":"Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells. Location: Nucleus (UniProt). Locus 6q23.3 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)","Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)","Paediatric low-grade glioma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/myb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}