{"entity":{"id":"mycl","kind":"target","name":"MYCL","aka":["MYCL proto-oncogene, bHLH transcription factor","bHLHe38","MYCL1"],"tldr":"MYCL (MYCL proto-oncogene, bHLH transcription factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma, Skin cancer and Melanoma.","summary":"UniProt has no function text for P12524; HGNC names it \"MYCL proto-oncogene, bHLH transcription factor\".\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming JQ1 and I-BET151. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.35, genetic association 0.00, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7555","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7555"},{"label":"UniProt P12524","url":"https://www.uniprot.org/uniprotkb/P12524/entry"},{"label":"NCBI Gene 4610","url":"https://www.ncbi.nlm.nih.gov/gene/4610"},{"label":"Ensembl ENSG00000116990","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116990"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["multiple-myeloma","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MYCL","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7555","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7555","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P12524","url":"https://www.uniprot.org/uniprotkb/P12524/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MYCL","url":"https://civicdb.org/features/3738","note":"1 evidence items, 0 assertions, 1 variants; diseases: Multiple Myeloma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000116990","url":"https://platform.opentargets.org/target/ENSG00000116990/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:7555","ensembl":"ENSG00000116990","uniprot":"P12524","entrez":"4610","biology":"UniProt has no function text for P12524; HGNC names it \"MYCL proto-oncogene, bHLH transcription factor\". Location: Nucleus (UniProt). Locus 1p34.2 (HGNC).","whereFound":["Multiple myeloma: CIViC evidence names this disease","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)"],"targetClass":"other","prevalence":[]},"route":"/targets/mycl/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}