{"entity":{"id":"myeov","kind":"target","name":"MYEOV","aka":["myeloma overexpressed","Myeloma-overexpressed gene protein"],"tldr":"MYEOV (Myeloma-overexpressed gene protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.","summary":"UniProt has no function text for Q96EZ4; HGNC names it \"myeloma overexpressed\".\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.62, somatic mutation 0.23). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7563","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7563"},{"label":"UniProt Q96EZ4","url":"https://www.uniprot.org/uniprotkb/Q96EZ4/entry"},{"label":"NCBI Gene 26579","url":"https://www.ncbi.nlm.nih.gov/gene/26579"},{"label":"Ensembl ENSG00000172927","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172927"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MYEOV","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:7563","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7563","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96EZ4","url":"https://www.uniprot.org/uniprotkb/Q96EZ4/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000172927","url":"https://platform.opentargets.org/target/ENSG00000172927/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"},{"label":"IntOGen MYEOV","url":"https://www.intogen.org/search?gene=MYEOV","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7563","ensembl":"ENSG00000172927","uniprot":"Q96EZ4","entrez":"26579","biology":"UniProt has no function text for Q96EZ4; HGNC names it \"myeloma overexpressed\". Locus 11q13.3 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 1 cohort (PRAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/myeov/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}