{"entity":{"id":"myh11","kind":"target","name":"MYH11","aka":["myosin heavy chain 11","Myosin-11","SMMHC","SMMS-1"],"tldr":"MYH11 (Myosin-11) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 5 more.","summary":"Muscle contraction.\n\nIntOGen calls it a driver in 10 cohorts (5 activating, 5 loss-of-function), covering Acute Myeloid Leukaemia, Invasive Breast Carcinoma, Cholangiocarcinoma, Head and Neck Squamous Cell Carcinoma, Low-Grade Glioma, NOS, Melanoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7569","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7569"},{"label":"UniProt P35749","url":"https://www.uniprot.org/uniprotkb/P35749/entry"},{"label":"NCBI Gene 4629","url":"https://www.ncbi.nlm.nih.gov/gene/4629"},{"label":"Ensembl ENSG00000133392","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000133392"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["prostate","breast-cancer","head-and-neck","nasopharyngeal","sarcoma","aml","cholangiocarcinoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MYH11","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:7569","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7569","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35749","url":"https://www.uniprot.org/uniprotkb/P35749/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen MYH11","url":"https://www.intogen.org/search?gene=MYH11","note":"driver in 10 cohorts (Act 5, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7569","ensembl":"ENSG00000133392","uniprot":"P35749","entrez":"4629","biology":"Muscle contraction. Location: Melanosome (UniProt). Locus 16p13.11 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 2 cohorts (PRAD, PROSTATE)","Breast cancer: IntOGen driver in 1 cohort (BRCA)","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)","Sarcomas: IntOGen driver in 1 cohort (SOFT_TISSUE)","Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/myh11/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}