{"entity":{"id":"myo18a","kind":"target","name":"MYO18A","aka":["myosin XVIIIA","Putative TGFB1-induced anti-apoptotic factor 1","KIAA0216","MysPDZ","TIAF1"],"tldr":"MYO18A (Putative TGFB1-induced anti-apoptotic factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.","summary":"Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.63, affected pathway 0.97, genetic association 0.00, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:31104","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31104"},{"label":"UniProt O95411","url":"https://www.uniprot.org/uniprotkb/O95411/entry"},{"label":"NCBI Gene 399687","url":"https://www.ncbi.nlm.nih.gov/gene/399687"},{"label":"Ensembl ENSG00000196535","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196535"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MYO18A","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:31104","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31104","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95411","url":"https://www.uniprot.org/uniprotkb/O95411/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000196535","url":"https://platform.opentargets.org/target/ENSG00000196535/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: leukaemia 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:31104","ensembl":"ENSG00000196535","uniprot":"O95411","entrez":"399687","biology":"Inhibits the cytotoxic effects of TNF and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. Location: Nucleus (UniProt). Locus 17q11.2 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)"],"targetClass":"other","prevalence":[]},"route":"/targets/myo18a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"}]}}