{"entity":{"id":"n4bp2","kind":"target","name":"N4BP2","aka":["NEDD4 binding protein 2","NEDD4-binding protein 2","B3BP"],"tldr":"N4BP2 (NEDD4-binding protein 2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Bladder & urothelial cancer and Biliary tract cancer.","summary":"Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon.\n\nIntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Cholangiocarcinoma, Hepatocellular Carcinoma, Upper Tract Urothelial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:29851","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29851"},{"label":"UniProt Q86UW6","url":"https://www.uniprot.org/uniprotkb/Q86UW6/entry"},{"label":"NCBI Gene 55728","url":"https://www.ncbi.nlm.nih.gov/gene/55728"},{"label":"Ensembl ENSG00000078177","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000078177"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["hcc","urothelial","cholangiocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"N4BP2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:29851","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29851","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86UW6","url":"https://www.uniprot.org/uniprotkb/Q86UW6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen N4BP2","url":"https://www.intogen.org/search?gene=N4BP2","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:29851","ensembl":"ENSG00000078177","uniprot":"Q86UW6","entrez":"55728","biology":"Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. May play a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon. Location: Cytoplasm (UniProt). Locus 4p14 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC)","Biliary tract cancer: IntOGen driver in 1 cohort (CHOL)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/n4bp2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"cholangiocarcinoma","kind":"cancer","name":"Biliary tract cancer (cholangiocarcinoma)","route":"/cancers/cholangiocarcinoma/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}]}}