{"entity":{"id":"nab2","kind":"target","name":"NAB2","aka":["NGFI-A binding protein 2","NGFI-A-binding protein 2","MADER"],"tldr":"NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.54, genetic association 0.00, somatic mutation 0.89).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7627","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7627"},{"label":"UniProt Q15742","url":"https://www.uniprot.org/uniprotkb/Q15742/entry"},{"label":"NCBI Gene 4665","url":"https://www.ncbi.nlm.nih.gov/gene/4665"},{"label":"Ensembl ENSG00000166886","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166886"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NAB2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7627","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7627","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q15742","url":"https://www.uniprot.org/uniprotkb/Q15742/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000166886","url":"https://platform.opentargets.org/target/ENSG00000166886/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:7627","ensembl":"ENSG00000166886","uniprot":"Q15742","entrez":"4665","biology":"Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Location: Nucleus (UniProt). Locus 12q13.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/nab2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}