{"entity":{"id":"naca","kind":"target","name":"NACA","aka":["nascent polypeptide associated complex subunit alpha","Nascent polypeptide-associated complex subunit alpha, muscle-specific form","NACA1","Alpha-NAC"],"tldr":"NACA (Nascent polypeptide-associated complex subunit alpha, muscle-specific form) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Melanoma and Basal cell carcinoma.","summary":"Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration.\n\nIntOGen calls it a driver in 4 cohorts (2 activating, 0 loss-of-function), covering Basal Cell Carcinoma, Bladder Urothelial Carcinoma, Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7629","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7629"},{"label":"UniProt E9PAV3","url":"https://www.uniprot.org/uniprotkb/E9PAV3/entry"},{"label":"NCBI Gene 4666","url":"https://www.ncbi.nlm.nih.gov/gene/4666"},{"label":"Ensembl ENSG00000196531","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196531"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["urothelial","melanoma","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NACA","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:7629","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7629","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt E9PAV3","url":"https://www.uniprot.org/uniprotkb/E9PAV3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen NACA","url":"https://www.intogen.org/search?gene=NACA","note":"driver in 4 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7629","ensembl":"ENSG00000196531","uniprot":"E9PAV3","entrez":"4666","biology":"Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organised assembly of thick and thin filaments of myofibril sarcomeres. Location: Cytoplasm; Nucleus (UniProt). Locus 12q13.3 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Melanoma: IntOGen driver in 2 cohorts (MEL)","Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/naca/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}