{"entity":{"id":"naf1","kind":"target","name":"NAF1","aka":["nuclear assembly factor 1 ribonucleoprotein","H/ACA ribonucleoprotein complex non-core subunit NAF1"],"tldr":"NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.43, genetic literature 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25126","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25126"},{"label":"UniProt Q96HR8","url":"https://www.uniprot.org/uniprotkb/Q96HR8/entry"},{"label":"NCBI Gene 92345","url":"https://www.ncbi.nlm.nih.gov/gene/92345"},{"label":"Ensembl ENSG00000145414","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145414"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NAF1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:25126","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25126","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96HR8","url":"https://www.uniprot.org/uniprotkb/Q96HR8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000145414","url":"https://platform.opentargets.org/target/ENSG00000145414/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:25126","ensembl":"ENSG00000145414","uniprot":"Q96HR8","entrez":"92345","biology":"RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. Location: Cytoplasm; Nucleus (UniProt). Locus 4q32.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/naf1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}