{"entity":{"id":"nbea","kind":"target","name":"NBEA","aka":["neurobeachin","Neurobeachin","KIAA1544","BCL8B","FLJ10197","LYST2"],"tldr":"NBEA (Neurobeachin) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Breast cancer, Colorectal cancer and 5 more.","summary":"Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.16, animal model 0.41, genetic association 0.62, somatic mutation 0.74). IntOGen calls it a driver in 14 cohorts (6 activating, 8 loss-of-function), covering Invasive Breast Carcinoma, Cervical Adenocarcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7648","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7648"},{"label":"UniProt Q8NFP9","url":"https://www.uniprot.org/uniprotkb/Q8NFP9/entry"},{"label":"NCBI Gene 26960","url":"https://www.ncbi.nlm.nih.gov/gene/26960"},{"label":"Ensembl ENSG00000172915","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172915"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","breast-cancer","colorectal","ovarian","cervical","esophageal","gastric","oesophageal-adenocarcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 6 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 8 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NBEA","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:7648","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7648","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NFP9","url":"https://www.uniprot.org/uniprotkb/Q8NFP9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000172915","url":"https://platform.opentargets.org/target/ENSG00000172915/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: ovarian cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen NBEA","url":"https://www.intogen.org/search?gene=NBEA","note":"driver in 14 cohorts (Act 6, LoF 8); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:7648","ensembl":"ENSG00000172915","uniprot":"Q8NFP9","entrez":"26960","biology":"Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Location: Cytoplasm; Membrane (UniProt). Locus 13q13.3 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 3 cohorts (HCC)","Breast cancer: IntOGen driver in 2 cohorts (BRCA)","Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD)","Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170); IntOGen driver in 1 cohort (OVT)","Cervical cancer: IntOGen driver in 1 cohort (CEAD)","Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/nbea/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}]}}