{"entity":{"id":"nbtxr3","kind":"drug","name":"NBTXR3 (hafnium oxide nanoparticles)","aka":["Hensify","JNJ-90301900"],"tldr":"NBTXR3 is Nanobiotix's radioenhancer: a single injection of hafnium oxide nanoparticles that makes ordinary radiotherapy hit harder inside the tumour. It carries a European CE mark for soft-tissue sarcoma and is in a phase 3 trial in head and neck cancer with Johnson and Johnson.","summary":"NBTXR3 was developed by Nanobiotix in Paris. In the Act.In.Sarc phase 2/3 trial, adding the nanoparticles to preoperative radiotherapy for locally advanced soft-tissue sarcoma doubled the rate of pathological complete response, and the product received a CE mark (as Hensify) in 2019. The NANORAY-312 phase 3 trial tests it with radiotherapy, with or without cetuximab, in elderly patients with head and neck cancer who cannot have cisplatin, under a 2023 licence to Johnson and Johnson; trials with immunotherapy in lung and other cancers continue.","status":"phase-3","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of NBTXR3","url":"https://clinicaltrials.gov/search?intr=NBTXR3"}],"tags":["radiation-wave3"],"related":[],"cancers":["sarcoma","head-and-neck"],"sections":[],"technologies":["radiosensitisers","imrt-igrt"],"targets":[],"drugs":[],"companies":["nanobiotix"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo radiation expansion","editedOn":"2026-09-16"},"code":"NBTXR3","modality":"Hafnium oxide nanoparticle radioenhancer, injected into the tumour","mechanism":"Crystalline hafnium oxide nanoparticles injected once into the tumour absorb X-rays far more strongly than tissue and release showers of electrons, multiplying the energy deposited inside the tumour without changing the dose to surrounding organs.","approvals":[{"region":"EU","year":2019,"indication":"CE mark: locally advanced soft-tissue sarcoma of the limb or trunk wall, with preoperative radiotherapy"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/nbtxr3/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"radiosensitisers","kind":"technology","name":"Radiosensitisers","route":"/technologies/radiosensitisers/"}],"company":[{"id":"nanobiotix","kind":"company","name":"Nanobiotix","route":"/companies/nanobiotix/"}]}}