{"entity":{"id":"nckipsd","kind":"target","name":"NCKIPSD","aka":["NCK interacting protein with SH3 domain","NCK-interacting protein with SH3 domain","AF3P21","SPIN90","ORF1","WASLBP","DIP1"],"tldr":"NCKIPSD (NCK-interacting protein with SH3 domain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.","summary":"Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:15486","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15486"},{"label":"UniProt Q9NZQ3","url":"https://www.uniprot.org/uniprotkb/Q9NZQ3/entry"},{"label":"NCBI Gene 51517","url":"https://www.ncbi.nlm.nih.gov/gene/51517"},{"label":"Ensembl ENSG00000213672","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213672"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NCKIPSD","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:15486","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15486","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NZQ3","url":"https://www.uniprot.org/uniprotkb/Q9NZQ3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen NCKIPSD","url":"https://www.intogen.org/search?gene=NCKIPSD","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:15486","ensembl":"ENSG00000213672","uniprot":"Q9NZQ3","entrez":"51517","biology":"Has an important role in stress fibre formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerisation and cell adhesion. Plays a role in angiogenesis. Location: Nucleus (UniProt). Locus 3p21.31 (HGNC).","whereFound":["Endometrial cancer: IntOGen driver in 1 cohort (UCEC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/nckipsd/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}