{"entity":{"id":"ncoa4","kind":"target","name":"NCOA4","aka":["nuclear receptor coactivator 4","Nuclear receptor coactivator 4","ARA70","ELE1","PTC3","DKFZp762E1112"],"tldr":"NCOA4 (Nuclear receptor coactivator 4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.","summary":"Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.21, somatic mutation 0.94).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7671","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7671"},{"label":"UniProt Q13772","url":"https://www.uniprot.org/uniprotkb/Q13772/entry"},{"label":"NCBI Gene 8031","url":"https://www.ncbi.nlm.nih.gov/gene/8031"},{"label":"Ensembl ENSG00000266412","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000266412"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"NCOA4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:7671","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7671","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13772","url":"https://www.uniprot.org/uniprotkb/Q13772/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000266412","url":"https://platform.opentargets.org/target/ENSG00000266412/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: thyroid cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:7671","ensembl":"ENSG00000266412","uniprot":"Q13772","entrez":"8031","biology":"Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis. Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy. Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion. Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation. In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Another study shows only weak behaviour as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR. Location: Cytoplasmic vesicle, autophagosome; Autolysosome; Nucleus; Chromosome (UniProt). Locus 10q11.22 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.54 with thyroid cancer (MONDO_0002108)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ncoa4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}