{"entity":{"id":"nct00002658","kind":"trial","name":"Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia","aka":[],"tldr":"A phase 3 trial of Filgrastim, Amsacrine, Cyclophosphamide, Cytarabine, Daunorubicin, Etoposide, Idarubicin, Mitoxantrone, Thioguanine and Tretinoin in Leukaemia, run by Medical Research Council, with a status the registry has not verified recently.","summary":"Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia is a phase 3 interventional study registered as NCT00002658 by Medical Research Council, with 2000 participants planned, started 1994-01. Interventions recorded: filgrastim, amsacrine, cyclophosphamide, cytarabine, daunorubicin hydrochloride, etoposide, idarubicin, mitoxantrone hydrochloride, thioguanine, tretinoin, allogeneic bone marrow transplantation, autologous bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy. Conditions recorded: Leukemia, Neutropenia.\n\nLinked to the drug Amsacrine because the registry names it among its interventions and Leukaemia among its conditions. Registry record only: no result has been read by an editor.","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT00002658","url":"https://clinicaltrials.gov/study/NCT00002658"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":["filgrastim","amsacrine","cyclophosphamide","cytarabine","daunorubicin","etoposide","idarubicin","mitoxantrone","thioguanine","tretinoin-atra"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT00002658","phase":"3","setting":"ACUTE MYELOID LEUKAEMIA TRIAL 12","sponsor":"Medical Research Council","enrolled":2000,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct00002658/","neighbours":{"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"}],"drug":[{"id":"amsacrine","kind":"drug","name":"Amsacrine","route":"/drugs/amsacrine/"},{"id":"cyclophosphamide","kind":"drug","name":"Cyclophosphamide","route":"/drugs/cyclophosphamide/"},{"id":"cytarabine","kind":"drug","name":"Cytarabine","route":"/drugs/cytarabine/"},{"id":"daunorubicin","kind":"drug","name":"Daunorubicin","route":"/drugs/daunorubicin/"},{"id":"etoposide","kind":"drug","name":"Etoposide","route":"/drugs/etoposide/"},{"id":"filgrastim","kind":"drug","name":"Filgrastim (G-CSF)","route":"/drugs/filgrastim/"},{"id":"idarubicin","kind":"drug","name":"Idarubicin","route":"/drugs/idarubicin/"},{"id":"mitoxantrone","kind":"drug","name":"Mitoxantrone","route":"/drugs/mitoxantrone/"},{"id":"thioguanine","kind":"drug","name":"Thioguanine","route":"/drugs/thioguanine/"},{"id":"tretinoin-atra","kind":"drug","name":"Tretinoin (all-trans retinoic acid, ATRA)","route":"/drugs/tretinoin-atra/"}]}}