{"entity":{"id":"nct00003436","kind":"trial","name":"Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia","aka":[],"tldr":"A phase 3 trial of Amsacrine, Asparaginase, Cytarabine, Daunorubicin, Etoposide, Methotrexate and Mitoxantrone in Leukaemia and Myelodysplastic syndromes / neoplasms, run by Medical Research Council, completed.","summary":"Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia is a phase 3 interventional study registered as NCT00003436 by Medical Research Council, with 2000 participants recorded, started 1998-07. Interventions recorded: amsacrine, asparaginase, cytarabine, daunorubicin hydrochloride, etoposide, methotrexate, mitoxantrone hydrochloride, therapeutic hydrocortisone, allogeneic bone marrow transplantation. Conditions recorded: Leukemia, Myelodysplastic Syndromes.\n\nLinked to the drug Amsacrine because the registry names it among its interventions and Leukaemia and Myelodysplastic syndromes / neoplasms among its conditions. Registry record only: no result has been read by an editor.","status":"completed","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT00003436","url":"https://clinicaltrials.gov/study/NCT00003436"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["leukaemia","mds"],"sections":[],"technologies":[],"targets":[],"drugs":["amsacrine","asparaginase","cytarabine","daunorubicin","etoposide","methotrexate","mitoxantrone"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT00003436","phase":"3","setting":"Medical Research Council Working Party on Leukaemia in Childhood Acute Myeloid Leukaemia Trial 12","sponsor":"Medical Research Council","enrolled":2000,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct00003436/","neighbours":{"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"mds","kind":"cancer","name":"Myelodysplastic syndromes / neoplasms (MDS)","route":"/cancers/mds/"}],"drug":[{"id":"amsacrine","kind":"drug","name":"Amsacrine","route":"/drugs/amsacrine/"},{"id":"asparaginase","kind":"drug","name":"Asparaginase (pegaspargase, calaspargase pegol, Erwinia asparaginase)","route":"/drugs/asparaginase/"},{"id":"cytarabine","kind":"drug","name":"Cytarabine","route":"/drugs/cytarabine/"},{"id":"daunorubicin","kind":"drug","name":"Daunorubicin","route":"/drugs/daunorubicin/"},{"id":"etoposide","kind":"drug","name":"Etoposide","route":"/drugs/etoposide/"},{"id":"methotrexate","kind":"drug","name":"Methotrexate","route":"/drugs/methotrexate/"},{"id":"mitoxantrone","kind":"drug","name":"Mitoxantrone","route":"/drugs/mitoxantrone/"}]}}