{"entity":{"id":"nct00005838","kind":"trial","name":"Combination Chemotherapy Plus Radiation Therapy With or Without AE-941 in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed By Surgery","aka":[],"tldr":"A phase 3 trial of Shark cartilage in Lung cancer and Non-small-cell lung cancer, run by National Cancer Institute (NCI), completed.","summary":"Combination Chemotherapy Plus Radiation Therapy With or Without AE-941 in Treating Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed By Surgery is a phase 3 interventional study registered as NCT00005838 by National Cancer Institute (NCI), with 756 participants recorded, started 2000-03 and reaching its primary completion in 2007-02. Interventions recorded: shark cartilage extract AE-941, placebo, cisplatin, vinorelbine tartrate, carboplatin, paclitaxel, radiation therapy. Conditions recorded: Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer, Squamous Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer.\n\nLinked to the technology Shark cartilage because the registry names it (\"shark cartilage\") among its interventions and Lung cancer and Non-small-cell lung cancer among its conditions. Registry record only: no result has been read by an editor.","status":"completed","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT00005838","url":"https://clinicaltrials.gov/study/NCT00005838"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["lung-cancer","nsclc"],"sections":[],"technologies":["shark-cartilage"],"targets":[],"drugs":["cisplatin","vinorelbine","carboplatin","paclitaxel"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT00005838","phase":"3","setting":"Multicenter, Open-Ended, Double-Blind, Placebo-Controlled, Phase III Study of AE-941 in Addition to Combined Modality Treatment (Chemotherapy/Radiotherapy) for Locally Advanced Unresectable Non-Small Cell Lung Cancer","sponsor":"National Cancer Institute (NCI)","enrolled":756,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct00005838/","neighbours":{"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"shark-cartilage","kind":"technology","name":"Shark cartilage (AE-941, Neovastat)","route":"/technologies/shark-cartilage/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"},{"id":"vinorelbine","kind":"drug","name":"Vinorelbine","route":"/drugs/vinorelbine/"}]}}