{"entity":{"id":"nct00045357","kind":"trial","name":"Autologous CD4+ antigen-specific T-cell clones in metastatic melanoma (Fred Hutchinson phase 1)","aka":[],"tldr":"A Seattle safety trial of helper T cells grown from patients' own blood to recognise melanoma. It ran from 2001 to 2008 and the registry posts no results.","summary":"The registry describes a phase I safety study of cellular adoptive immunotherapy using autologous CD4+ antigen-specific T-cell clones in metastatic melanoma, started in November 2001 and completed in August 2008, with an estimated enrolment of 18 (ClinicalTrials.gov NCT00045357). Cassian Yee is listed as study chair; the sponsor is Fred Hutchinson Cancer Center with the National Cancer Institute as collaborator (ClinicalTrials.gov NCT00045357). No results are posted.","status":"completed","asOf":"2026-11-05","links":[{"label":"ClinicalTrials.gov NCT00045357","url":"https://clinicaltrials.gov/study/NCT00045357"}],"tags":[],"related":[],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["fred-hutch","nci"],"pathways":[],"terms":["endogenous-t-cell-therapy"],"trials":[],"people":["cassian-yee"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo agent (Claude Opus 5.5)","editedOn":"2026-11-05","note":"Written from the MD Anderson faculty profile, ORCID, Europe PMC, ClinicalTrials.gov v2, SEC EDGAR and each organisation's own site, read on 5 November 2026."},"nct":"NCT00045357","phase":"1","setting":"Metastatic melanoma: autologous CD4+ antigen-specific T-cell clones","sponsor":"Fred Hutchinson Cancer Center, with the National Cancer Institute","result":"No results posted on ClinicalTrials.gov.","started":"2001-11","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct00045357/","neighbours":{"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"institution":[{"id":"fred-hutch","kind":"institution","name":"Fred Hutchinson Cancer Center","route":"/institutions/fred-hutch/"},{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}],"term":[{"id":"endogenous-t-cell-therapy","kind":"term","name":"Endogenous T-cell therapy","route":"/terms/endogenous-t-cell-therapy/"}],"person":[{"id":"cassian-yee","kind":"person","name":"Cassian Yee","route":"/people/cassian-yee/"}]}}