{"entity":{"id":"nct01074970","kind":"trial","name":"BRE09-146: postoperative cisplatin with or without rucaparib","aka":[],"tldr":"This completed study tested extra treatment for breast cancer remaining after chemotherapy and surgery. Adding the tested low-dose rucaparib regimen did not significantly improve two-year disease-free survival.","summary":"Registry completed, last updated 2024-09-19. Postoperative TNBC or BRCA-mutated breast cancer with residual tumour greater than 2 cm or persistent nodal involvement after neoadjuvant therapy. The registry records 135 enrolled; the paper reports 128 randomized. Low rucaparib exposure and the historical regimen limit extrapolation to other PARP strategies.","status":"completed","asOf":"2026-10-10","links":[{"label":"ClinicalTrials.gov NCT01074970","url":"https://clinicaltrials.gov/study/NCT01074970"}],"tags":[],"related":[],"cancers":["breast-cancer","tnbc"],"sections":[],"technologies":[],"targets":["parp"],"drugs":["rucaparib","cisplatin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-kalra-bre09-146-rucaparib-npj-2021"],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT01074970","phase":"2","setting":"Postoperative TNBC or BRCA-mutated breast cancer with residual tumour greater than 2 cm or persistent nodal involvement after neoadjuvant therapy","sponsor":"Hoosier Cancer Research Network","started":"2010-02","enrolled":135,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct01074970/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"drug":[{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"rucaparib","kind":"drug","name":"Rucaparib","route":"/drugs/rucaparib/"}],"paper":[{"id":"paper-kalra-bre09-146-rucaparib-npj-2021","kind":"paper","name":"BRE09-146: cisplatin with or without rucaparib after preoperative breast chemotherapy","route":"/key-papers/paper-kalra-bre09-146-rucaparib-npj-2021/"}]}}