{"entity":{"id":"nct01349881","kind":"trial","name":"S0820, Adenoma and Second Primary Prevention Trial","aka":["PACES"],"tldr":"A phase 3 trial of eflornithine (DFMO) in colorectal cancer, run by SWOG Cancer Research Network, active but no longer recruiting.","summary":"S0820, Adenoma and Second Primary Prevention Trial is a phase 3, randomised interventional study registered as NCT01349881 by SWOG Cancer Research Network, with a registry enrolment figure of 354 participants, started 2013-08-23 and due to reach its primary completion in 2027-09-15. Interventions recorded: Eflornithine placebo & sulindac placebo; eflornithine & sulindac placebo; Eflornithine placebo & sulindac; Eflornithine plus sulindac. Conditions listed: Colorectal Neoplasms. Primary outcome: Event rate, defined as rate of high-risk adenoma or second primary colorectal cancer (CRC). Colorectal eligibility wording from the registry: \"* History of Stage 0-III colon or rectal cancer with primary resection 1 year previously\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT01349881","url":"https://clinicaltrials.gov/study/NCT01349881"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["eflornithine"],"companies":["cancer-prevention-pharmaceuticals","swog"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT01349881","phase":"3","setting":"A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients With Stage 0-III Colon or Rectal Cancer, Phase III - Preventing Adenomas of the Colon With Eflornithine and Sulindac (PACES)","sponsor":"SWOG Cancer Research Network","enrolled":354,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct01349881/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"eflornithine","kind":"drug","name":"Eflornithine (DFMO)","route":"/drugs/eflornithine/"}],"company":[{"id":"cancer-prevention-pharmaceuticals","kind":"company","name":"Cancer Prevention Pharmaceuticals","route":"/companies/cancer-prevention-pharmaceuticals/"},{"id":"swog","kind":"company","name":"SWOG Cancer Research Network","route":"/companies/swog/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}