{"entity":{"id":"nct02022358","kind":"trial","name":"Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays?","aka":[],"tldr":"A phase 2 trial of Glucarpidase, Methotrexate and Leucovorin in Osteosarcoma, run by University College, London, recorded as terminated on the registry.","summary":"Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays? is a phase 2 interventional study registered as NCT02022358 by University College, London, with 34 participants recorded, started 2007-07 and due to reach its primary completion in 2015-06. Interventions recorded: Glucarpidase, Methotrexate, Folinic Acid. Conditions recorded: Osteosarcoma, Spindle Cell Sarcoma of Bone.\n\nLinked to the drug Glucarpidase because the registry names it among its interventions and Osteosarcoma among its conditions. Registry record only: no result has been read by an editor.","asOf":"2026-09-22","links":[{"label":"ClinicalTrials.gov NCT02022358","url":"https://clinicaltrials.gov/study/NCT02022358"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["osteosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":["glucarpidase","methotrexate","leucovorin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT02022358","phase":"2","setting":"A Randomised, Cross-over Phase II Study to Investigate the Efficacy and Safety of Glucarpidase for Routine Use After High Dose Methotrexate in Patients With Bone Sarcoma","sponsor":"University College, London","enrolled":34,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct02022358/","neighbours":{"cancer":[{"id":"osteosarcoma","kind":"cancer","name":"Osteosarcoma","route":"/cancers/osteosarcoma/"}],"drug":[{"id":"glucarpidase","kind":"drug","name":"Glucarpidase","route":"/drugs/glucarpidase/"},{"id":"leucovorin","kind":"drug","name":"Leucovorin (folinic acid)","route":"/drugs/leucovorin/"},{"id":"methotrexate","kind":"drug","name":"Methotrexate","route":"/drugs/methotrexate/"}]}}