{"entity":{"id":"nct02497820","kind":"trial","name":"Finding the Best Dose of Aspirin to Prevent Lynch Syndrome Cancers","aka":["CaPP3 Israel"],"tldr":"A phase 3 trial of aspirin in colorectal cancer, run by Tel-Aviv Sourasky Medical Center, not yet recruiting.","summary":"Finding the Best Dose of Aspirin to Prevent Lynch Syndrome Cancers is a phase 3, randomised interventional study registered as NCT02497820 by Tel-Aviv Sourasky Medical Center, with a registry enrolment figure of 1800 participants, started 2016-09 and due to reach its primary completion in 2027-09. Interventions recorded: Aspirin. Conditions listed: Lynch Syndrome I (Site-specific Colonic Cancer). Primary outcome: cancer preventive properties of enteric coated aspirin in Lynch syndrome are dose sensitive by comparing overall cumulative Lynch syndrome cancer. Sites: Israel. No results are recorded here; the registry entry is the source.","status":"planned","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT02497820","url":"https://clinicaltrials.gov/study/NCT02497820"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["colon-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":["aspirin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT02497820","phase":"3","setting":"A Randomised Double Blind Dose Non-inferiority Trial of a Daily Dose of 600mg Versus 300mg Versus 100mg of Enteric Coated Aspirin as a Cancer Preventive in Carriers of a Germline Pathological Mismatch Repair Gene Defect, Lynch Syndrome","sponsor":"Tel-Aviv Sourasky Medical Center","enrolled":1800,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct02497820/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"}],"drug":[{"id":"aspirin","kind":"drug","name":"Aspirin","route":"/drugs/aspirin/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}