{"entity":{"id":"nct02813824","kind":"trial","name":"Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome","aka":["AAS-Lynch"],"tldr":"A phase 3 trial in colorectal cancer, run by Assistance Publique - Hôpitaux de Paris, active but no longer recruiting.","summary":"Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome is a phase 3, randomised interventional study registered as NCT02813824 by Assistance Publique - Hôpitaux de Paris, with a registry enrolment figure of 852 participants, started 2017-11-14 and due to reach its primary completion in 2026-06-15. Interventions recorded: Acetylsalicylic acid lysinate 300 mg; Placebo (for Aspirin 300); Acetylsalicylic acid lysinate 100 mg; Placebo 100 (for Aspirin 100). Conditions listed: Lynch Syndrome. Primary outcome: Number of patients with at least one adenoma seen on chromo-endoscopy 48 months after complete withdrawal of polyps and initiation of treatment (aspirin or placebo). Colorectal eligibility wording from the registry: \"* Aged more than 25 years, et aged more than 18 years with an early familial history and any reason to perform a colonoscopy every 2 years\". Sites: France. No results are recorded here; the registry entry is the source.","status":"active","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT02813824","url":"https://clinicaltrials.gov/study/NCT02813824"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer","msi-high-colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT02813824","phase":"3","setting":"Assessment of the Effect of a Daily Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome","sponsor":"Assistance Publique - Hôpitaux de Paris","enrolled":852,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct02813824/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}