{"entity":{"id":"nct03051464","kind":"trial","name":"Randomizing Two Radiotherapy Boost Options to Avoid Rectal Cancer Surgery","aka":["MORPHEUS"],"tldr":"A phase 2/3 trial in colorectal cancer, run by Sir Mortimer B. Davis - Jewish General Hospital, now recruiting.","summary":"Randomizing Two Radiotherapy Boost Options to Avoid Rectal Cancer Surgery is a phase 2/3, randomised interventional study registered as NCT03051464 by Sir Mortimer B. Davis - Jewish General Hospital, with a registry enrolment figure of 131 participants, started 2017-04-25 and due to reach its primary completion in 2028-01. Interventions recorded: Complete responders and Non-complete responders; Chemoradiation + EBRT Boost; Chemoradiation + HDRBT Boost. Conditions listed: Stage II Rectal Cancer; Organ Preservation; Non-operative Treatment; Rectal Cancer (Stage III); Rectal Cancer Patients. Primary outcome: TME-free survival. Colorectal eligibility wording from the registry: \"* Rectal cancer patients, clinically staged as T2-T3a,b N0-1 by MRI or endoscopic/trans-rectal ultrasound\". Sites: Canada, United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03051464","url":"https://clinicaltrials.gov/study/NCT03051464"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03051464","phase":"2/3","setting":"A Phase III Study Testing Two Dose Escalation Strategies to Increase the Population of Complete Responders After Radiation Therapy in the Context of Organ Preservation for Patients With Rectal Cancer","sponsor":"Sir Mortimer B. Davis - Jewish General Hospital","enrolled":131,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03051464/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}