{"entity":{"id":"nct03303495","kind":"trial","name":"A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC","aka":[],"tldr":"A phase 3 trial of bevacizumab (glioblastoma use) in colorectal cancer, run by Sun Yat-sen University, now recruiting.","summary":"A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC is a phase 3, randomised interventional study registered as NCT03303495 by Sun Yat-sen University, with a registry enrolment figure of 280 participants, started 2011-11-14 and due to reach its primary completion in 2026-12-31. Interventions recorded: Bevacizumab; CPT-11; 5-FU Bolus; 5-FU Infusion; l-LV (dl-LV). Conditions listed: Colorectal Neoplasms; Neoplasm Metastasis; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms. Primary outcome: Progression-free survival (PFS). Colorectal eligibility wording from the registry: \"Histologically-confirmed inoperable colorectal adenocarcinoma excluding vermiform appendix cancer and anal canal cancer\". Sites: China. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03303495","url":"https://clinicaltrials.gov/study/NCT03303495"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer","colon-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":["bevacizumab-glioma"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03303495","phase":"3","setting":"A Multinational, Randomized, Phase III Study of FOLFIRI With/Without Bevacizumab Versus Irinotecan With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer","sponsor":"Sun Yat-sen University","enrolled":280,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03303495/","neighbours":{"cancer":[{"id":"colon-cancer","kind":"cancer","name":"Colon cancer (adenocarcinoma of the colon)","route":"/cancers/colon-cancer/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"drug":[{"id":"bevacizumab-glioma","kind":"drug","name":"Bevacizumab (glioblastoma use)","route":"/drugs/bevacizumab-glioma/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}