{"entity":{"id":"nct03485209","kind":"trial","name":"Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors","aka":[],"tldr":"A phase 2 trial of Tisotumab vedotin, Pembrolizumab, Carboplatin and Cisplatin in colorectal cancer, non-small-cell lung cancer, pancreatic ductal adenocarcinoma and head and neck squamous cell carcinoma, run by Seagen, a wholly owned subsidiary of Pfizer, active and no longer recruiting.","summary":"Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors is a phase 2 interventional study registered as NCT03485209 by Seagen, a wholly owned subsidiary of Pfizer, with 350 participants enrolled, started 2018-06-25 and due to reach its primary completion in 2026-03-20. Interventions recorded: tisotumab vedotin, pembrolizumab, carboplatin and cisplatin.","status":"active","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT03485209","url":"https://clinicaltrials.gov/study/NCT03485209"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["colorectal","nsclc","pancreatic","head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":["tisotumab-vedotin","pembrolizumab","carboplatin","cisplatin"],"companies":["genmab","merck"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT03485209","phase":"2","setting":"Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors","sponsor":"Seagen, a wholly owned subsidiary of Pfizer","enrolled":350,"outcomes":[]},"route":"/trials/nct03485209/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"cisplatin","kind":"drug","name":"Cisplatin","route":"/drugs/cisplatin/"},{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"},{"id":"tisotumab-vedotin","kind":"drug","name":"Tisotumab vedotin","route":"/drugs/tisotumab-vedotin/"}],"company":[{"id":"genmab","kind":"company","name":"Genmab","route":"/companies/genmab/"},{"id":"merck","kind":"company","name":"Merck & Co. (MSD)","route":"/companies/merck/"}]}}