{"entity":{"id":"nct03516708","kind":"trial","name":"Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer","aka":[],"tldr":"A phase 1/2 trial of epacadostat in colorectal cancer, run by Washington University School of Medicine, now recruiting.","summary":"Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer is a phase 1/2, interventional study registered as NCT03516708 by Washington University School of Medicine, with a registry enrolment figure of 49 participants, started 2020-01-06 and due to reach its primary completion in 2027-07-15. Interventions recorded: Epacadostat; Short-course radiation therapy; CAPOX chemotherapy; FOLFOX chemotherapy. Conditions listed: Rectal Cancer. Primary outcome: Phase I only: Recommended phase II dose (RP2D) of epacadostat with standard of care radiation and chemotherapy in preoperative treatment of locally advanced rectal cancer; Phase II Treatment Cohort only: Neoadjuvant Rectal (NAR) Score. Colorectal eligibility wording from the registry: \"* Newly diagnosed pathologically-confirmed locally advanced rectal cancer (defined by 8th edition AJCC stage 2 or 3, or stage 1 not eligible for sphincter-sparing surgery) with plans to proceed with total neoadjuvant short course radiation as part of their neoadjuvant therapy as confirmed by treatin\". Sites: United States. No results are recorded here; the registry entry is the source.","status":"recruiting","asOf":"2026-09-24","links":[{"label":"ClinicalTrials.gov NCT03516708","url":"https://clinicaltrials.gov/study/NCT03516708"}],"tags":["ctgov-ingest","colorectal-deep-dive"],"related":[],"cancers":["rectal-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":["epacadostat"],"companies":["incyte"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT03516708","phase":"1/2","setting":"Phase I/II Study of Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer","sponsor":"Washington University School of Medicine","enrolled":49,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/nct03516708/","neighbours":{"cancer":[{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"epacadostat","kind":"drug","name":"Epacadostat","route":"/drugs/epacadostat/"}],"company":[{"id":"incyte","kind":"company","name":"Incyte","route":"/companies/incyte/"}],"term":[{"id":"colorectal-trials-open-today","kind":"term","name":"Colorectal cancer trials open today (registry snapshot)","route":"/terms/colorectal-trials-open-today/"}]}}